• Renaud Tissier, Kazutoshi Hamanaka, Atsushi Kuno, James C Parker, Michael V Cohen, and James M Downey.
• Department of Physiology, University of South Alabama, College of Medicine, Mobile, Alabama 36688, USA.
• J. Am. Coll. Cardiol. 2007 Feb 6;49(5):601-5.

ObjectivesWe tested whether total liquid ventilation (TLV) can be used to rapidly cool and protect the infarcting heart.BackgroundDecreasing myocardial temperature during ischemia is a powerful cardioprotective strategy, but clinical application has been impaired by lack of practical methodology to quickly cool the heart.MethodsWe performed 30-min coronary artery occlusion/3-h reperfusion in rabbits. Upon occlusion, rabbits underwent either oxygen (Gas), normothermic liquid (Liquid Warm), or cold liquid (Liquid Cool) ventilation.ResultsLeft atrial chamber temperature decreased to 32.4 degrees +/- 0.2 degrees C within 5 min of onset of cold TLV. Blood gases were within acceptable limits during TLV. In the Liquid Warm group, perfluorocarbon inhalation did not alter infarct size compared with Gas (37.7 +/- 1.3% and 42.5 +/- 4.9% of risk zone, respectively). However, infarction was significantly reduced in the Liquid Cool group (4.0 +/- 0.5%). Cooling only during the initial 30 min of reperfusion did not reduce infarction.ConclusionsTotal liquid ventilation can elicit rapid cardioprotective cooling during ischemia.

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