• Cynthia Harrison-Felix, Gale Whiteneck, Michael J Devivo, Flora M Hammond, and Amitabh Jha.
• Research Department, Craig Hospital, Englewood, Colorado 80113, USA. charrison-felix@craighospital.org
• J Head Trauma Rehabil. 2006 Jan 1;21(1):22-33.

ObjectiveTo investigate causes of death in individuals with traumatic brain injury (TBI).DesignRetrospective cohort study.SettingUtilized data from the TBI Model Systems National Database, the Social Security Death Index, death certificates, and the US population age-race-gender-cause-specific mortality rates for 1994.PatientsTwo thousand one hundred forty individuals with TBI completing inpatient rehabilitation in 1 of 15 National Institute on Disability and Rehabilitation Research-funded TBI Model Systems of Care between 1988 and 2001, and surviving past 1 year postinjury.Main Outcome MeasuresPrimary cause of death based on the International Classification of Diseases--9th Revision--Clinical Modification-coded death certificates.ResultsIndividuals with TBI were about 37 times more likely to die of seizures, 12 times more likely to die of septicemia, 4 times more likely to die of pneumonia, and about 3 times more likely to die of other respiratory conditions (excluding pneumonia), digestive conditions, and all external causes of injury/poisoning than were individuals in the general population of similar age, gender, and race.ConclusionLong-term follow-up of individuals with TBI should increase vigilance for, and prevention of, diagnoses frequently causing death (circulatory disorders) and diagnoses with a high relative risk of causing death in this population (seizures, septicemia, respiratory and digestive conditions, and external causes of injury).

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