• Journal of anesthesia · Jan 2008

    Monitoring of vecuronium-induced neuromuscular blockade during one-lung ventilation.

    • Yuhji Saitoh, Tsutomu Oshima, and Yoshinori Nakata.
    • Department of Anesthesiology, Satte General Hospital, 4-14-24 Higashi, Satte, Saitama, 340-0114, Japan.
    • J Anesth. 2008 Jan 1;22(4):378-84.

    PurposeWe investigated the monitoring of neuromuscular blockade caused by vecuronium in patients receiving one-lung ventilation (OLV) anesthesia for lung surgery.MethodsEighteen adult patients requiring OLV for lung surgery (OLV group) and 18 undergoing two-lung ventilation (TLV) for colon surgery (control group) were enrolled in this study. In the two groups, anesthesia was maintained with sevoflurane, fentanyl, and epidural lidocaine. Time from vecuronium 0.1 mg.kg(-1) to the onset of neuromuscular blockade; times to the return of T1, T2, T3, or T4 (the first, second, third, or fourth response of the train-of-four [TOF]); and recovery of T1/control or TOF ratio (T4/T1) were compared between the two groups.ResultsTime to the onset of neuromuscular blockade in the OLV group was similar to that in the control group (289 +/- 74 vs 270 +/- 85 s [mean +/- SD]; P = 0.482). Times from vecuronium to the return of T1, T2, T3, or T4 in the OLV group did not significantly differ from those in the control group (21.9 +/- 7.0 vs 25.8 +/- 6.7 min for T1; P = 0.099). T1/control in the OLV group was significantly higher than that in the control group 50-120 min after vecuronium (P < 0.05). The TOF ratio did not differ significantly between the two groups.ConclusionDuring OLV for lung surgery, recovery of T1/control is accelerated in anesthetized patients receiving vecuronium.

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