• Bull. World Health Organ. · Jan 1997

    Comparative Study

    The WHO Global Programme for Vaccines and Immunization Vaccine Trial Registry.

    • S E Robertson, M V Mayans, S Horsfall, P F Wright, J Clemens, B Ivanoff, and P H Lambert.
    • Vaccine Research and Development Unit, World Health Organization, Geneva, Switzerland.
    • Bull. World Health Organ. 1997 Jan 1;75(4):295-305.

    AbstractIn 1995, the WHO Global Programme for Vaccines and Immunization established a Vaccine Trial Registry. As of September 1996, this registry included 50 WHO-supported vaccine trials, of which 25 (50%) were completed studies. The vaccines most frequently tested have been against measles (9 trials), poliovirus (8 trials), cholera (8 trials), enterotoxigenic Escherichia coli (4 trials), and pneumococcus (4 trials). Nearly 80% of these trials have been conducted in developing countries, with the largest number being in Africa. Among the 25 completed trials, outcomes measured were immune response (24 trials), adverse reactions (13 trials), morbidity (4 trials), and mortality (1 trial). WHO's contributions to these studies include direct funding, assistance with study design, site visits, data analysis, vaccine procurement, and vaccine potency testing.

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