• Curr Opin Crit Care · Dec 2015

    Review

    Nutritional controversies in critical care: revisiting enteral glutamine during critical illness and injury.

    • John A Stroster, Selman Uranues, and Rifat Latifi.
    • aDivision of Trauma, Critical Care, Burns, and Emergency Surgery, Department of Surgery, University of Arizona, Tucson, Arizona, USA bSection for Surgical Research, Clinical Division of General Surgery, Department of Surgery, Medical University of Graz, Graz, Austria.
    • Curr Opin Crit Care. 2015 Dec 1; 21 (6): 527-30.

    Purpose Of ReviewThis article examines some of the articles that inspired recent changes to critical care guidelines related to glutamine in enteral nutrition.Recent FindingsTwo recent multicenter randomized controlled trials involving enteral glutamine have reported increased mortality rates in groups of mechanically ventilated adult patients, while demonstrating no additional benefits to other outcomes, such as nosocomial infections.SummaryRecent studies suggest that enteral glutamine supplementation may not provide significant clinical benefits to adult patients on mechanical ventilation with multiple organ failure, but more information is still needed when attempting to apply these results to other groups of critical care patients.

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