• Thorac Cardiovasc Surg · Oct 2008

    Can dantrolene protect spinal cord against ischemia/reperfusion injury? An experimental study.

    • C U Kocogullari, M Emmiler, M Cemek, O Sahin, A Aslan, E Ayva, L Tur, M E Buyukokuroglu, I Demirkan, and A Cekirdekci.
    • Department of Cardiovascular Surgery, Afyon Kocatepe University Medical Faculty, Afyon, Turkey. cevdetkoc@hotmail.com
    • Thorac Cardiovasc Surg. 2008 Oct 1;56(7):406-11.

    BackgroundThe aim of this experimental study was to investigate the possible protective effect of dantrolene on neuronal injury induced by aortic ischemia/reperfusion (I/R).MethodsNineteen rabbits were divided into three groups: sham (group 1, n = 5, no I/R), control (group 2, n = 7, only I/R) and dantrolene (group 3, n = 7, dantrolene + I/R). Abdominal aortic occlusion between the renal arteries and iliac bifurcations was carried out for 30 min. The spinal cord functions of the subjects were assessed using the Tarlov Scale. Blood and cord tissue samples were taken for biochemical and histopathological evaluation.ResultsTarlov scores in group 3 were significantly higher than in group 2 ( P < 0.05). In group 3, the MDA levels of the spinal cord decreased significantly compared to those of group 2 ( P < 0.05). In rabbits with I/R (group 2), the GSH levels of the spinal cord decreased significantly compared to those of group 1 ( P < 0.01), but dantrolene pretreatment significantly prevented a decrease in GSH levels. Histopathological examination showed that group 3 had less vascular proliferation, hemorrhage, edema and neuron loss than group 2.ConclusionsIt was concluded that dantrolene applied after ischemia might help protect the spinal cord against ischemia/reperfusion injury.

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