• A John Camm, Günter Breithardt, Harry Crijns, Paul Dorian, Peter Kowey, Jean-Yves Le Heuzey, Ihsen Merioua, Laurence Pedrazzini, Eric N Prystowsky, Peter J Schwartz, Christian Torp-Pedersen, and William Weintraub.
• St. George's University of London, Cranmer Terrace, London, United Kingdom. jcamm@sgul.ac.uk.
• J. Am. Coll. Cardiol. 2011 Jul 26;58(5):493-501.

ObjectivesRECORDAF is the first worldwide, prospective, observational survey of management of atrial fibrillation (AF) in unselected, community-based patients.BackgroundPrimary outcomes were therapeutic success and clinical outcomes associated with rhythm-control and rate-control strategies.MethodsPatients with recent-onset AF were included (n = 5,604). Treatment strategy (rhythm control or rate control) was noted at baseline. Follow-up was 12 months. Therapeutic success required that strategy was unchanged without clinical events. Further maintenance of sinus rhythm was required in the rhythm-control group, and heart rate ≤80 beats/min in the rate-control group.ResultsData from 5,171 patients were assessable. Therapeutic success was 54% overall (rhythm control 60% vs. rate control 47%), a result driven by control of AF: rhythm control, 81% vs. rate control, 74%. After adjustment for propensity score quintiles, the rhythm-control strategy was significantly related to superior therapeutic success (odds ratio: 1.34, 95% confidence interval: 1.15 to 1.55; p = 0.0002). Clinical events occurred in 18% of patients. The arrhythmia management strategy was not predictive of clinical events. The type (persistent), presence at baseline visit, and duration (>3 months) of AF, together with age older than 75 years and the presence of heart failure, predicted progression to permanent AF. The choice of rhythm control reduced the likelihood of AF progression (odds ratio: 0.20, 95% confidence interval: 0.17 to 0.25; p < 0.0001).ConclusionsClinical outcomes in AF patients were driven mainly by hospitalizations for arrhythmia/proarrhythmia and other cardiovascular causes, but not by the choice of rate or rhythm strategy. Rhythm-control patients progressed less rapidly to permanent AF.Copyright © 2011 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

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