• Cytokine Growth Factor Rev. · Jun 2013

    Review

    The BAFF/APRIL system: emerging functions beyond B cell biology and autoimmunity.

    • Fabien B Vincent, Damien Saulep-Easton, William A Figgett, Kirsten A Fairfax, and Fabienne Mackay.
    • Department of Immunology, Monash University, Central Clinical School, Alfred Medical Research and Education Precinct (AMREP), 89 Commercial Road, Melbourne, Victoria 3004, Australia. fabien.vincent@monash.edu
    • Cytokine Growth Factor Rev. 2013 Jun 1;24(3):203-15.

    AbstractThe BAFF system plays a key role in the development of autoimmunity, especially in systemic lupus erythematosus (SLE). This often leads to the assumption that BAFF is mostly a B cell factor with a specific role in autoimmunity. Focus on BAFF and autoimmunity, driven by pharmaceutical successes with the recent approval of a novel targeted therapy Belimumab, has relegated other potential roles of BAFF to the background. Far from being SLE-specific, the BAFF system has a much broader relevance in infection, cancer and allergy. In this review, we provide the latest views on additional roles of the BAFF system in health and diseases, as well as an update on BAFF and autoimmunity, with particular focus on current clinical trials.Copyright © 2013 Elsevier Ltd. All rights reserved.

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