• Transfus Med Rev · Oct 2012

    Review

    Reducing transfusion-related acute lung injury risk: evidence for and approaches to transfusion-related acute lung injury mitigation.

    • Robert S Makar, Amy Powers, and Christopher P Stowell.
    • Blood Transfusion Service, Department of Pathology, Massachusetts General Hospital, Boston, MA 02114-2696, USA. rmakar@partners.org
    • Transfus Med Rev. 2012 Oct 1;26(4):305-20.

    AbstractTransfusion-related acute lung injury (TRALI) is a major cause of transfusion-related morbidity and mortality. Although the pathogenesis of TRALI is incompletely understood, substantial data from hemovigilance systems, large case series, clinical trials, and animal models have identified antileukocyte antibodies as a major precipitant and have contributed to the development of concrete interventions to reduce the risk of TRALI. This review presents the clinical data supporting specific donor management strategies to reduce TRALI risk and their observed clinical efficacy. Novel strategies that use the donor health questionnaire combined with testing are discussed, and important challenges that remain going forward are explored.Copyright © 2012 Elsevier Inc. All rights reserved.

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