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- R H Myers, D S Sax, M Schoenfeld, E D Bird, P A Wolf, J P Vonsattel, R F White, and J B Martin.
- J. Neurol. Neurosurg. Psychiatr. 1985 Jun 1;48(6):530-4.
AbstractTwenty-five patients with late-onset Huntington's disease were studied; motor impairment appeared at age 50 years or later. The average age at onset of chorea was 57.5 years, with an average age at diagnosis of 63.1 years. Approximately 25% of persons affected by Huntington's disease exhibit late onset. A preponderance of maternal transmission was noted in late-onset Huntington's disease. The clinical features resembled those of mid-life onset Huntington's disease but progressed more slowly. Neuropathological evaluation of two cases reveal less severe neuronal atrophy than for mid-life onset disease.
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