• Perihan Ergin Ozcan, Simru Tugrul, N Mert Senturk, Elvan Uludag, Nahit Cakar, Lutfi Telci, and Figen Esen.
• Department of Anesthesiology and Intensive Care, Istanbul University, Istanbul, Turkey. pergin@istanbul.edu.tr <pergin@istanbul.edu.tr>
• J. Cardiothorac. Vasc. Anesth. 2007 Dec 1;21(6):827-31.

ObjectiveThe purpose of this study was to investigate the effect of magnesium sulfate on pain management for post-thoracotomy patients.DesignA prospective, randomized, controlled clinical study.SettingUniversity hospital.ParticipantsTwenty-four patients undergoing thoracotomy.InterventionsAfter thoracotomy operations, patients were assigned to 2 groups. The control group received intravenous morphine (0.5 mg/h infusion, 0.3 mg patient-controlled anesthesia dose, 15-minute lockout time) via patient-controlled analgesia, and the magnesium group received magnesium sulfate (30-mg/kg bolus, 10 mg/kg/h infusion for 48 hours) plus the same patient-controlled analgesia protocol.Measurements And Main ResultsVisual analog scale for pain score, sedation score, mean arterial pressure, heart rate, and valid and invalid analgesic demand were recorded. Serum magnesium levels were determined at postanesthesia care unit admission, at 24 hours, and at 48 hours. Side effects were also recorded. There were no significant differences between groups with respect to demographics, sedation score, and pain score. Cumulative mean morphine consumption was found to be higher in the control group compared with the magnesium group at 4, 8, and 48 hours (5.6 +/- 1 mg v 3.2 +/- 0.6 mg [p < 0.0001], 10.2 +/- 1.8 mg v 7.2 +/- 1.6 mg [p = 0.0003), and 40.2 +/- 4.5 mg v 34.8 +/- 6.3 mg [p = 0.02], respectively).ConclusionPostoperative use of magnesium sulfate reduced opioid consumption for pain after thoracotomy operations.

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