• Hideki Fukuda, Shigeaki Kurita, Masashi Kawamoto, and Osafumi Yuge.
• Department of Anesthesiology and Critical Care, Division of Clinical Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734-8551.
• Masui. 2006 Oct 1;55(10):1278-81.

BackgroundEntropy, a newly available electroencephalographic monitor, demonstrates two parameters, response entropy (RE) and state entropy (SE). The aim of this study is to compare RE and SE with bispectral index (BIS) during anesthetic induction with propofol.MethodsFifteen patients received target controlled infusion of propofol starting at 3 microg x ml(-1). We measured RE, SE and BIS and recorded effect-site concentrations of propofol at three sedation levels: VR1; conscious state before infusion of propofol, VR2; no response to verbal command, and VR3; no response to verbal command and shaking. Spearman rank correlations and prediction probability for sedation level were analyzed.ResultsEffect-site concentrations of propofol at VR1, VR2, and VR3 were 0, 1.8 +/- 0.7, and 2.4 +/- 0.7, respectively. All three parameters showed significant correlations with sedation levels. Prediction probability values of SE, RE, and BIS were 0.905, 0.894, and 0.890, respectively.ConclusionsResponse entropy and SE can provide similar information as BIS about the sedation level with propofol.

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