• Anaesthesia · Jun 1996

    Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial

    A comparison of the induction characteristics of sevoflurane and halothane in children.

    • A Black, M R Sury, L Hemington, R Howard, A Mackersie, and D J Hatch.
    • Department of Anaesthesia, Great Ormond Street Hospital for Children NHS Trust, London.
    • Anaesthesia. 1996 Jun 1;51(6):539-42.

    AbstractThe induction characteristics of sevoflurane and halothane were compared in 81 children aged 6 months to 6 years. The mean time taken to achieve loss of eyelash reflex was significantly shorter with sevoflurane than with halothane (sevoflurane, mean time (SD) 1 min 41 s (35 s), halothane, mean time (SD) 2 min 17 s (43 s), t = 4.11, p = < 0.01). The mean time taken to complete induction (to achieve steady spontaneous ventilation and small pupils with central gaze) was also shorter in children induced with sevoflurane (sevoflurane, mean time (SD) 3 min 58 s (1 min 8 s), halothane, mean time (SD) 4 min 50 s, (1 min 27 s), t = 2.29, p = 0.027). Effects on heart rate, blood pressure and oxygen saturation during induction were similar for both agents. There were no major complications during induction with either halothane or sevoflurane.

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