• Mariëlle C van de Veerdonk, Taco Kind, J Tim Marcus, Gert-Jan Mauritz, Martijn W Heymans, Harm-Jan Bogaard, Anco Boonstra, Koen M J Marques, Nico Westerhof, and Anton Vonk-Noordegraaf.
• Department of Pulmonary Diseases, VU University Medical Center, Amsterdam, the Netherlands.
• J. Am. Coll. Cardiol. 2011 Dec 6;58(24):2511-9.

ObjectivesThe purpose of this study was to examine the relationship between changes in pulmonary vascular resistance (PVR) and right ventricular ejection fraction (RVEF) and survival in patients with pulmonary arterial hypertension (PAH) under PAH-targeted therapies.BackgroundDespite the fact that medical therapies reduce PVR, the prognosis of patients with PAH is still poor. The primary cause of death is right ventricular (RV) failure. One possible explanation for this apparent paradox is the fact that a reduction in PVR is not automatically followed by an improvement in RV function.MethodsA cohort of 110 patients with incident PAH underwent baseline right heart catheterization, cardiac magnetic resonance imaging, and 6-min walk testing. These measurements were repeated in 76 patients after 12 months of therapy.ResultsTwo patients underwent lung transplantation, 13 patients died during the first year, and 17 patients died in the subsequent follow-up of 47 months. Baseline RVEF (hazard ratio [HR]: 0.938; p = 0.001) and PVR (HR: 1.001; p = 0.031) were predictors of mortality. During the first 12 months, changes in PVR were moderately correlated with changes in RVEF (R = 0.330; p = 0.005). Changes in RVEF (HR: 0.929; p = 0.014) were associated with survival, but changes in PVR (HR: 1.000; p = 0.820) were not. In 68% of patients, PVR decreased after medical therapy. Twenty-five percent of those patients with decreased PVR showed a deterioration of RV function and had a poor prognosis.ConclusionsAfter PAH-targeted therapy, RV function can deteriorate despite a reduction in PVR. Loss of RV function is associated with a poor outcome, irrespective of any changes in PVR.Copyright © 2011 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

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