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Randomized Controlled Trial
A preliminary study comparing methadone and buprenorphine in patients with chronic pain and coexistent opioid addiction.
- Anne M Neumann, Richard D Blondell, Urmo Jaanimägi, Amanda K Giambrone, Gregory G Homish, Jacqueline R Lozano, Urszula Kowalik, and Mohammadreza Azadfard.
- Primary Care Research Institute, Department of Family Medicine, State University of New York at Buffalo, Buffalo, New York, USA.
- J Addict Dis. 2013 Jan 1;32(1):68-78.
AbstractPatients with opioid addiction who receive prescription opioids for treatment of nonmalignant chronic pain present a therapeutic challenge. Fifty-four participants with chronic pain and opioid addiction were randomized to receive methadone or buprenorphine/naloxone. At the 6-month follow-up examination, 26 (48.1%) participants who remained in the study noted a 12.75% reduction in pain (P = 0.043), and no participants in the methadone group compared to 5 in the buprenorphine group reported illicit opioid use (P = 0.039). Other differences between the two conditions were not found. Long-term, low-dose methadone or buprenorphine/naloxone treatment produced analgesia in participants with chronic pain and opioid addiction.
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