• Michael T Froehler, Ali Kooshkabadi, Rachel Miller-Lotan, Shany Blum, Slava Sher, Andrew Levy, and Rafael J Tamargo.
• Interventional Neuroradiology, University of California Los Angeles, 757 Westwood Plaza, Ste 2129, Los Angeles, CA 90095, USA. mfroehler@mednet.ucla.edu
• J Clin Neurosci. 2010 Sep 1;17(9):1169-72.

AbstractVasospasm after subarachnoid hemorrhage (SAH) is attributable to inflammation and oxidative stress associated with extracellular hemoglobin (Hb). Haptoglobin (Hp) binds free Hb and the Hp-Hb complex is cleared by macrophages, and the Hp-2 isoform of Hp is associated with more oxidative stress and more severe vasospasm. We hypothesized that treatment with an anti-oxidant, the glutathione peroxidase mimetic SYI-2074, would reduce vasospasm after SAH in Hp-2 mice. We found that SAH induced significant vasospasm in Hp-2 mice (lumen patency reduced to 65.9%), but no vasospasm was seen in mice that received SYI-2074 after SAH (lumen patency of 98.7%). We conclude that vasospasm after SAH in Hp-2 mice can be prevented with SYI-2074, suggesting that oxidative stress contributes significantly to vasospasm.Copyright 2010 Elsevier Ltd. All rights reserved.

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