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Pediatr. Infect. Dis. J. · Sep 2012
Serial T-SPOT.TB and quantiFERON-TB-Gold In-Tube assays to monitor response to antitubercular treatment in Italian children with active or latent tuberculosis infection.
- Elena Chiappini, Francesca Bonsignori, Giusi Mangone, Luisa Galli, Rachele Mazzantini, Sara Sollai, Chiara Azzari, and Maurizio de Martino.
- Department of Science for Woman and Child Health, Meyer University Hospital, Florence, Italy.
- Pediatr. Infect. Dis. J. 2012 Sep 1;31(9):974-7.
AbstractWe performed a prospective study to investigate T-SPOT.TB and QuantiFERON-TB Gold In-Tube (QFT-G-IT) dynamics during antitubercular treatment in active tuberculosis (TB) or latent TB. Eighteen children with latent TB and 26 with TB were enrolled. At 6 months of follow-up reversion rate was 5.88% (95% CI:0-13.79) for QFT-G-IT; 9.09% (95% CI:0.59-17.58) for T-SPOT.TB (P=0.921) in TB cases. Significant decline in quantitative response was observed exclusively in TB cases. Our results suggest that serial IGRA have limited use in children receiving antitubercular treatment.
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