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- Anjali N Kunz and Itzhak Brook.
- Department of Pediatrics, Uniformed Services University of the Health Sciences, 5207 Elsmere Avenue, Bethesda, MD 20814, USA. akunz@usuhs.mil
- Chemotherapy. 2010 Jan 1;56(6):492-500.
AbstractThe increasing emergence of serious multidrug-resistant (MDR) Gram-negative infections has led to a new health-care crisis. These infections predominately include MDR Pseudomonas aeruginosa, extended-spectrum beta-lactamase-producing Enterobacteriaceae and MDR Acinetobacter baumannii. These organisms are present in a variety of clinical settings, but there is a distinct paucity of antibiotics to effectively treat these infections. The increasing use of broad-spectrum antibiotics and lack of good stewardship have contributed to the increase in these MDR organisms. This review focuses on the main MDR Gram-negative infections contributing to the current crisis in health care, their mechanisms of resistance and various treatment options for empiric therapy.Copyright © 2010 S. Karger AG, Basel.
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