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Am J Geriatr Psychiatry · Nov 2003
Clinical TrialA pilot open-label trial of citalopram for restless activity and aberrant motor behaviors in Alzheimer disease.
- Douglas W Scharre, Rebecca A Davis, Jennifer L Warner, Shu-Ing Chang, and David Q Beversdorf.
- Division of Cognitive Neurology, Department of Neurology, The Ohio State University, Columbus, OH 43210, USA. scharre.1@osu.edu
- Am J Geriatr Psychiatry. 2003 Nov 1;11(6):687-91.
ObjectiveIn a prospective, open-label pilot study in probable-Alzheimer disease (AD) outpatients, the authors investigated the efficacy of citalopram to reduce restless activity and aberrant motor behaviors.MethodsNineteen subjects were evaluated with Neuropsychiatric Inventory subscale and total scores.ResultsThere was a significant decline in aberrant motor behaviors and overall behavior problems at 4, 8, and 12 weeks.ConclusionThis study provides initial evidence that citalopram may be effective in reducing aberrant motor behaviors in AD. However, because of the potential biases of an open-label study, these findings need to be confirmed in a larger, controlled trial.
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