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Randomized Controlled Trial Comparative Study Clinical Trial
Pipecuronium versus high dose vecuronium. I. A comparison of speed of onset and cumulation during isoflurane anaesthesia.
- W Harrop-Griffiths, N Fauvel, M Plumley, and S Feldman.
- Department of Anaesthesia, St Mary's Hospital, London.
- Anaesthesia. 1992 Feb 1;47(2):105-6.
AbstractThe onset time and tendency to cumulation of pipecuronium and high-dose vecuronium were studied during nitrous oxide anaesthesia supplemented with isoflurane. Pipecuronium 0.06 mg.kg-1 had a similar duration of action to vecuronium 0.015 mg.kg-1 (42 vs 49 min). Patients who received vecuronium had a shorter onset time of neuromuscular blockade (p less than 0.01). The use of pipecuronium was associated with marked cumulation.
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