• Evgeny Pokushalov, Alexander Romanov, Giorgio Corbucci, Sergey Artyomenko, Vera Baranova, Alex Turov, Natalya Shirokova, Alexander Karaskov, Suneet Mittal, and Jonathan S Steinberg.
• State Research Institute of Circulation Pathology, Novosibirsk, Russia. E.Pokushalov@gmail.com
• J. Am. Coll. Cardiol. 2012 Sep 25;60(13):1163-70.

ObjectivesThe aim of this prospective randomized study was to assess the impact of renal artery denervation in patients with a history of refractory atrial fibrillation (AF) and drug-resistant hypertension who were referred for pulmonary vein isolation (PVI).BackgroundHypertension is the most common cardiovascular condition responsible for the development and maintenance of AF. Treating drug-resistant hypertension with renal denervation has been reported to control blood pressure, but any effect on AF is unknown.MethodsPatients with a history of symptomatic paroxysmal or persistent AF refractory to ≥2 antiarrhythmic drugs and drug-resistant hypertension (systolic blood pressure >160 mm Hg despite triple drug therapy) were eligible for enrolment. Consenting patients were randomized to PVI only or PVI with renal artery denervation. All patients were followed ≥1 year to assess maintenance of sinus rhythm and to monitor changes in blood pressure.ResultsTwenty-seven patients were enrolled, and 14 were randomized to PVI only, and 13 were randomized to PVI with renal artery denervation. At the end of the follow-up, significant reductions in systolic (from 181 ± 7 to 156 ± 5, p < 0.001) and diastolic blood pressure (from 97 ± 6 to 87 ± 4, p < 0.001) were observed in patients treated with PVI with renal denervation without significant change in the PVI only group. Nine of the 13 patients (69%) treated with PVI with renal denervation were AF-free at the 12-month post-ablation follow-up examination versus 4 (29%) of the 14 patients in the PVI-only group (p = 0.033).ConclusionsRenal artery denervation reduces systolic and diastolic blood pressure in patients with drug-resistant hypertension and reduces AF recurrences when combined with PVI.Copyright © 2012 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

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