• Matthew T Goodus, Nadine A Kerr, Ruchika Talwar, David Buziashvili, Jennifer E C Fragale, Kevin C H Pang, and Steven W Levison.
• 1 Department of Pharmacology, Physiology, and Neuroscience, Rutgers University-New Jersey Medical School , Newark, New Jersey.
• J. Neurotrauma. 2016 Aug 15; 33 (16): 1522-34.

AbstractReactions of both astrocytes and microglia to central nervous system injury can be beneficial or detrimental to recovery. To gain insights into the functional importance of gliosis, we developed a new model of adolescent closed-head injury (CHI) and interrogated the behavioral, physiological, and cellular outcomes after a concussive CHI in leukemia inhibitory factor (LIF) haplodeficient mice. These mice were chosen because LIF is important for astrocyte and microglial activation. Behaviorally, the LIF haplodeficient animals were equally impaired 4 h after the injury, but in the subsequent 2 weeks, the LIF haplodeficient mice acquired more severe motor and sensory deficits, compared with wild type mice. The prolonged accumulation of neurological impairment was accompanied by desynchronization of the gliotic response, increased cell death, axonal degeneration, diminished callosal compound action potential, and hypomyelination. Our results clearly show that LIF is an essential injury-induced cytokine that is required to prevent the propagation of secondary neurodegeneration.

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