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AJNR Am J Neuroradiol · Dec 2011
ReviewPseudoprogression and pseudoresponse: imaging challenges in the assessment of posttreatment glioma.
- L C Hygino da Cruz, I Rodriguez, R C Domingues, E L Gasparetto, and A G Sorensen.
- Department of Radiology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. celsohygino@hotmail.com
- AJNR Am J Neuroradiol. 2011 Dec 1;32(11):1978-85.
AbstractThe current standard of care for newly diagnosed cases of high-grade glioma is surgical resection followed by RT with concurrent chemotherapy. The most widely used criteria for assessing treatment response are based on a 2D measurement of the enhancing area on MR imaging known as the Macdonald Criteria. Recently, nontumoral increases (pseudoprogression) and decreases (pseudoresponse) in enhancement have been found, and these can confuse outcome evaluation. Here we review pseudoprogression and pseudoresponse and describe how better understanding of these phenomena can aid interpretation.
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