• M Montard, C Chopin, B Delbosc, and M Muhieddine.
• Service d'Ophtalmologie, CHU Jean Minjoz, Besançon.
• J Fr Ophtalmol. 1999 Feb 1;22(1):14-20.

PurposeTo compare the efficacy and safety of topical diclofenac and tetracaine in reducing ocular pain after photorefractive keratectomy.SettingOphthalmology Department, Minjoz Hospital, Besançon, France.MethodsSeventy-four patients were randomized to receive either tetracaine 1% or diclofenac 0.1% after undergoing PRK. Tetracaine was instilled at 30 minute intervals for 24 hours. Diclofenac was instilled four times a day for 3 days. All patients were allowed to use oral Diantalvic (paracetamol-noramidopyrine) as a rescue analgesic if the study medications failed to control the ocular pain. Visual analog pain charts were used to record pain levels every hour for 30 hours after surgery. A subjective questionnaire was to be completed by the patient to evaluate discomfort every day for 3 days. Computer analysis of photography performed at D0, D1, D3, was used to evaluate the rate of epithelial closure.ResultsWomen had significantly more pain. Patients in the diclofenac group had significantly less pain. No statistically significant difference was seen in the rate of epithelial closure.ConclusionDiclofenac is more effective than tetracaine to reduce ocular pain and functional symptoms.

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