-
Pediatr Crit Care Me · Nov 2012
The need for and feasibility of a pediatric ventilation trial: reflections on a survey among pediatric intensivists*.
- Martin C J Kneyber and Peter C Rimensberger.
- Division of Pediatric Intensive Care, Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, Groningen, The Netherlands. m.c.j.kneyber@bkk.umcg.nl
- Pediatr Crit Care Me. 2012 Nov 1;13(6):632-8.
ObjectiveTo explore what design would be reasonable, acceptable, and feasible for a pediatric trial investigating the effect of low tidal volume ventilation.DesignA two-round modified Delphi approach among pediatric intensivists with a visible special interest in mechanical ventilation.SettingsNone.SubjectsPediatric intensivists.InterventionsNone.Measurements And ResultsIn the first questionnaire "experts" classified 64 items as "important," "not so important" or "not important" (June 2010). The second questionnaire included the 29 items having been classified by more than 50% of the experts as being "important" in the first questionnaire that needed to be ranked in order of importance (August 2010). Twenty-nine of 50 (64%) experts responded to the first questionnaire, and 28 of the 29 initial responders (96.6%) to the second questionnaire. Actual expert opinion favored the following: age of study population 0 yrs to 2 yrs, expected duration of ventilation ≥ 48 hrs, and stratification by the severity of hypoxemia (cutoff PaO(2)/FIO(2) < 200). The two study arms should compare the effect of 6 mL/kg vs. 10 mL/kg on mortality. However, these views of the experts face two major issues. First, 10 mL/kg does not represent standard of care. Second, numerous uncertainties render mortality unsuitable as primary measure of outcome including a large sample size (>1500).ConclusionsActual expert opinion favored investigating the effect of 6 mL/kg vs.10 mL/kg on mortality. Such a design suffers from various serious criticisms. Therefore, and in our opinion, a pediatric Acute Respiratory Distress Syndrome Network trial is not realistic.
Notes
Knowledge, pearl, summary or comment to share?You can also include formatting, links, images and footnotes in your notes
- Simple formatting can be added to notes, such as
*italics*
,_underline_
or**bold**
. - Superscript can be denoted by
<sup>text</sup>
and subscript<sub>text</sub>
. - Numbered or bulleted lists can be created using either numbered lines
1. 2. 3.
, hyphens-
or asterisks*
. - Links can be included with:
[my link to pubmed](http://pubmed.com)
- Images can be included with:
![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
- For footnotes use
[^1](This is a footnote.)
inline. - Or use an inline reference
[^1]
to refer to a longer footnote elseweher in the document[^1]: This is a long footnote.
.