• Bernhard Meyer, Florian Ringel, Yaroslav Winter, Annika Spottke, Nadir Gharevi, Judith Dams, Monika Balzer-Geldsetzer, Ines K Mueller, Thomas Klockgether, Johannes Schramm, Horst Urbach, and Richard Dodel.
• Department of Neurosurgery, Klinikum rechts der Isar, Technical University Munich, Rudolf-Bultmannstrasse 8, Munich, Germany.
• Cerebrovasc. Dis. 2010 Jan 1;30(4):423-31.

BackgroundAneurysmal subarachnoid haemorrhage (SAH) is a devastating disease with high mortality and disability. The data from large longitudinal studies on health-related quality of life (HRQoL) in patients with SAH are limited. The objective was to investigate HRQoL in patients after SAH and to identify predictors of HRQoL.Methods113 patients with aneurysmal SAH were assigned to either neurosurgery (n = 57) or endovascular coiling (n = 56). Clinical assessments (Barthel Index, modified Rankin Scale) and evaluation of HRQoL [36-Item Short-Form Survey, EuroQol (EQ5D), EQ visual analogue scale (EQ VAS)] were performed at discharge, and at 6 and 12 months of follow-up. Independent predictors of HRQoL were determined using multiple regression analysis.ResultsHRQoL in SAH patients was considerably reduced compared to the normal population. At discharge, 92.2% of the patients had moderate or severe problems on the EQ5D. The EQ VAS score was 57.8 +/- 19.3. However, HRQoL still showed improvement from 3 months up to 1 year. At 12 months after SAH, the EQ VAS score was approximately 12-14% higher than at discharge. The independent predictors of decreased HRQoL included female gender, severe SAH, functional disability, depression, a lower level of education and the lack of a stable partnership.ConclusionsThe long-term HRQoL outcome after SAH is unfavourable. HRQoL outcome measures should be included in future studies to provide better evidence of the long-term outcomes after SAH. In addition, the independent determinants of HRQoL identified in this study should be considered in the healthcare programmes aimed at increasing the HRQoL in SAH survivors.Copyright (c) 2010 S. Karger AG, Basel.

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