• Young Hwa Jung, Juyoung Lee, Han-Suk Kim, Seung Han Shin, Jin A Sohn, Ee-Kyung Kim, and Jung-Hwan Choi.
• Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea.
• Pediatr Crit Care Me. 2013 Jan 1;14(1):70-3.

ObjectiveTo evaluate clinical applicability of noninvasive hemoglobin (Hb) measurement with a pulse CO-oximeter in neonates.DesignProspective comparison study.SettingNeonatal ICU.PatientsFifty-six preterm and term infants with median age = 20 days (range = 1-98 days) and median weight = 1,440 g (range = 530-4,230 g).InterventionsHb measurements by Pulse CO-Oximetry (Masimo Radical-7) were recorded immediately prior to venous samplings.Measurements And Main ResultsThe collected data were compared with the corresponding venous Hb level obtained in laboratory testing, and a total of 137 data pairs were analyzed. Noninvasive Hb values measured with a pulse CO-oximeter were significantly correlated with the venous Hb levels (correlation coefficient, r = 0.758; p < 0.001). Hb values measured with a pulse CO-oximeter were higher than those measured with a laboratory hematology analyzer (13.3 ± 2.6g/dL vs. 12.5 ± 3.1g/dL). In terms of the agreement between the laboratory analyzer and the pulse CO-oximeter, 94.8% of the measurements fell within two standard deviations of the mean difference.ConclusionNoninvasive Hb measurements with Pulse CO-Oximetry provide clinically acceptable accuracy, and they were significantly correlated with laboratory Hb measurement in neonates. In terms of the clinical applicability, noninvasive Hb monitoring with a pulse CO-oximeter could be useful in the early detection of Hb changes in neonates.

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