• Brain Stimul · May 2015

    Safety Study of Transcranial Static Magnetic Field Stimulation (tSMS) of the Human Cortex.

    • A Oliviero, M C Carrasco-López, M Campolo, Y A Perez-Borrego, V Soto-León, J J Gonzalez-Rosa, A M Higuero, B A Strange, J Abad-Rodriguez, and G Foffani.
    • FENNSI Group, Hospital Nacional de Parapléjicos, SESCAM, Toledo, Spain. Electronic address: antonioo@sescam.jccm.es.
    • Brain Stimul. 2015 May 1; 8 (3): 481-5.

    BackgroundTranscranial static magnetic field stimulation (tSMS) in humans reduces cortical excitability.ObjectiveThe objective of this study was to determine if prolonged tSMS (2 h) could be delivered safely in humans. Safety limits for this technique have not been described.MethodstSMS was applied for 2 h with a cylindric magnet on the occiput of 17 healthy subjects. We assessed tSMS-related safety aspects at tissue level by measuring levels of neuron-specific enolase (NSE, a marker of neuronal damage) and S100 (a marker of glial reactivity and damage). We also included an evaluation of cognitive side effects by using a battery of visuomotor and cognitive tests.ResultstSMS did not induce any significant increase in NSE or S100. No cognitive alteration was detected.ConclusionsOur data indicate that the application of tSMS is safe in healthy human subjects, at least within these parameters.Copyright © 2015 Elsevier Inc. All rights reserved.

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