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- P A Borg and H J Krijnen.
- Department of Anaesthesiology, Academic Hospital Groningen, The Netherlands.
- Clin J Pain. 1996 Mar 1;12(1):63-8.
ObjectiveTo determine the clinical usefulness of the long-term intrathecal administration of midazolam and clonidine in patients with refractory neurogenic and musculoskeletal pain.SettingPain Centre, Academic Hospital Groningen, Groningen, The Netherlands.PatientsFour patients with chronic benign neurogenic and musculoskeletal pain, not responding to conventional analgesic therapy. OUTCOME-MEASURES: Visual Analogue Score, Activities of Daily Living.ResultsThe intrathecal administration of midazolam and clonidine produced almost immediate and nearly complete pain relief. Even with continuous use, tolerance seemed to be no problem, and side effects appear to be minimal.ConclusionIntrathecal infusion of midazolam and clonidine produced promising results in four patients with refractory chronic benign pain. Further research will be necessary to determine the efficacy and the risk-to-benefit ratio of long-term administration of this combination.
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