• Ole Solheim, Tonni Franke Johansen, Johan Cappelen, Geirmund Unsgård, and Tormod Selbekk.
• *Department of Neurosurgery, St. Olav's University Hospital, Trondheim, Norway; ‡Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway; §National Competence Centre for Ultrasound and Image-Guided Therapy, St. Olav's University Hospital, Trondheim, Norway; ¶Department of Acoustics, SINTEF ICT, Trondheim, Norway; ‖Department of Medical Technology, SINTEF Technology and Society, Trondheim, Norway.
• Neurosurgery. 2015 Nov 5.

BackgroundAnatomic orientation in transsphenoidal surgery can be difficult, and residual tumors are common. A major limitation of both direct microscopy and endoscopic visualization is the inability to see below the surface of the surgical field to confirm the location of vessels, nerves, tumor remnants, and normal pituitary tissue.ObjectiveTo present our initial experience with a new forward-looking, custom-designed ultrasound probe for transsellar imaging.MethodsThe center frequency of the prototype tightly curved linear array, bayonet-shaped probe is 12 MHz. Twenty-four patients with pituitary adenomas were included after informed consent.ResultsWith the use of transsellar ultrasound, we could confirm the location of important neurovascular structures and improve the extent of resection in 4 of 24 cases, as rated subjectively by the operating surgeons. Image quality was good. In 17 patients (71%), biochemical cures and/or complete resections were confirmed at 3 months.ConclusionWe found the images from our custom-designed ultrasound probe to be clinically helpful for anatomic orientation during surgery, and the technology is potentially helpful for improving the extent of resection during transsphenoidal surgery. This quick and flexible form of intraoperative imaging in transsphenoidal surgery could be of great support for surgeons in both routine use and difficult cases. The concept of transsellar intraoperative ultrasound imaging can be further refined and developed.

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