• Marina de Tommaso, Filippo Brighina, Brigida Fierro, Vito Devito Francesco, Roberto Santostasi, Vittorio Sciruicchio, Eleonora Vecchio, Claudia Serpino, Paolo Lamberti, and Paolo Livrea.
• Neurophysiopathology of Pain Unit, Neurological and Psychiatric Sciences Department, Neurological Clinic, Policlinico, University of Bari Aldo Moro, Piazza Giulio Cesare 11, 70124, Bari, Italy. m.detommaso@neurol.uniba.it
• J Headache Pain. 2010 Dec 1; 11 (6): 505512505-12.

AbstractThe aim of this study was to examine the effects of high-frequency (HF) repetitive transcranial magnetic stimulation (rTMS) of the left primary motor cortex (M1) on subjective pain and evoked responses induced by laser stimulation (LEPs) of the contralateral hand and supraorbital zone in a cohort of migraine patients without aura during the inter-critical phase, and to compare the effects with those of non-migraine healthy controls. Thirteen migraine patients and 12 sex- and age-matched controls were evaluated. Each rTMS session consisted of 1,800 stimuli at a frequency of 5 Hz and 90% motor threshold intensity. Sham (control) rTMS was performed at the same stimulation position. The vertex LEP amplitude was reduced at the trigeminal and hand levels in the sham-placebo condition and after rTMS to a greater extent in the migraine patients than in healthy controls, while the laser pain rating was unaffected. These results suggest that HF rTMS of motor cortex and the sham procedure can both modulate pain-related evoked responses in migraine patients.

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