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Ann Med Interne (Paris) · Oct 1999
Review Case Reports[Hepatotoxicity caused by therapeutic doses of paracetamol in alcoholics. Report of 2 cases of fatal hepatitis in cirrhosis].
- A Mofredj, J F Cadranel, B Darchy, J C Barbare, A Cazier, V Pras, and M Biour.
- Service de Réanimation, Centre Hospitalier Laennec, Creil.
- Ann Med Interne (Paris). 1999 Oct 1;150(6):507-11.
AbstractParacetamol is a widely used medication as it is an effective analgesic and antipyretic. Because of the absence of gastro-intestinal side effects, it has been used as the analgesic of choice for alcoholic patients. Hepatotoxicity is dose-related and generally occurs in patients who absorb more than 125 mg/kg/j. However, cases of severe liver damage have been reported after absorption of therapeutic doses of paracetamol in alcoholics. We report 2 cases with a fatal outcome and discuss the mechanisms of toxicity, the prognostic factors and treatment of such event.
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