• Resuscitation · Feb 2012

    Case Reports

    Neurologic recovery after therapeutic hypothermia in patients with post-cardiac arrest myoclonus.

    • Jason M Lucas, Michael N Cocchi, Justin Salciccioli, Jessica A Stanbridge, Romergryko G Geocadin, Susan T Herman, and Michael W Donnino.
    • Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, United States.
    • Resuscitation. 2012 Feb 1; 83 (2): 265-9.

    AbstractEarly myoclonus in comatose survivors of cardiac arrest, even when it is not myoclonic status epilepticus (MSE), is considered a sign of severe global brain ischemia and has been associated with high rates of mortality and poor neurologic outcomes. We report on three survivors of primary circulatory cardiac arrests who had good neurologic outcomes (two patients with a CPC score=1 and one patient with a CPC score=2) after mild therapeutic hypothermia, despite exhibiting massive myoclonus within the first 4h after return of spontaneous circulation. The concept that early myoclonus heralds a uniformly poor prognosis may need to be reconsidered in the era of post-cardiac arrest mild therapeutic hypothermia.Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

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