• Jennifer A Muszynski, James Sartori, Lisa Steele, Randall Frost, Wei Wang, Nadeem Khan, Anthony Lee, Ada Lin, Mark W Hall, and Onsy Ayad.
• Department of Pediatrics, Nationwide Children's Hospital, Columbus, OH, USA. jennifer.muszynski@nationwidechildrens.org
• Pediatr Crit Care Me. 2013 Jun 1; 14 (5): 533-8.

ObjectiveTo test the hypothesis that successful implementation of a care bundle designed to prevent nosocomial airway infection will be associated with decreased incidence of ventilator-associated tracheobronchitis.DesignProspective pre- and post interventional.SettingPICU at an academic medical centerPatients: All patients admitted to the PICU who received invasive mechanical ventilation for greater than or equal to 48 hours between March 1, 2009, and December 31, 2011.InterventionMultidisciplinary, unit wide implementation of an evidence-based care bundle to prevent ventilator-associated airway infection.Measurements And Main ResultsThere were 725 patients included in the analysis (338 patients preintervention and 387 patients postintervention). Baseline ventilator-associated tracheobronchitis rate in the preintervention period was 3.9 cases per 1,000 ventilator days compared with 1.8 cases per 1,000 ventilator days postintervention (p = 0.04, Fisher exact test). Compared with patients without ventilator-associated tracheobronchitis or ventilator-associated pneumonia, patients with ventilator-associated tracheobronchitis had fewer ventilator-free days in 28 days (4.9 vs 22; p < 0.0001, Mann-Whitney U test) and fewer ICU-free days in 28 days (0.5 vs 19; p < 0.0001, Mann-Whitney U test). These relationships remained significant after adjusting for covariates by multivariable linear regression.ConclusionsSuccessful implementation of a care bundle to prevent ventilator-associated infection was associated with decreased incidence of ventilator-associated tracheobronchitis. Development of ventilator-associated tracheobronchitis was independently associated with adverse outcomes in our cohort of pediatric ICU patients.

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