• Victor D Dinglas, Minxuan Huang, Kristin A Sepulveda, Mariela Pinedo, Ramona O Hopkins, Elizabeth Colantuoni, Dale M Needham, and NIH NHLBI ARDS Network.
• Outcomes After Critical Illness and Surgery (OACIS) Group, Johns Hopkins University, 1830 E Monument Street, 5th floor, 21205 Baltimore, MD, USA. dale.needham@jhmi.edu.
• Bmc Med Res Methodol. 2015 Jan 1;15:5.

BackgroundEffective strategies for contacting and recruiting study participants are critical in conducting clinical research. In this study, we conducted two sequential randomized controlled trials of mail- and telephone-based strategies for contacting and recruiting participants, and evaluated participant-related variables' association with time to survey completion and survey completion rates. Subjects eligible for this study were survivors of acute lung injury who had been previously enrolled in a 12-month observational follow-up study evaluating their physical, cognitive and mental health outcomes, with their last study visit completed at a median of 34 months previously.MethodsEligible subjects were contacted to complete a new research survey as part of two randomized trials, initially using a randomized mail-based contact strategy, followed by a randomized telephone-based contact strategy for non-responders to the mail strategy. Both strategies focused on using either a personalized versus a generic approach. In addition, 18 potentially relevant subject-related variables (e.g., demographics, last known physical and mental health status) were evaluated for association with time to survey completion.ResultsOf 308 eligible subjects, 67% completed the survey with a median (IQR) of 3 (2, 5) contact attempts required. There was no significant difference in the time to survey completion for either randomized trial of mail- or phone-based contact strategy. Among all subject-related variables, age ≤40 years and minority race were independently associated with a longer time to survey completion.ConclusionWe found that age ≤40 years and minority race were associated with a longer time to survey completion, but personalized versus generic approaches to mail- and telephone-based contact strategies had no significant effect. Repeating both mail and telephone contact attempts was important for increasing survey completion rate.Trial RegistrationNCT00719446.

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