• Peter Dodek, Gerald Chanques, Glen Brown, Monica Norena, Maja Grubisic, Hubert Wong, and Samir Jaber.
• Center for Health Evaluation and Outcome Sciences, Vancouver, BC, Canada. pedodek@interchange.ubc.ca
• BMJ Qual Saf. 2012 Sep 1;21(9):715-21.

PurposeUse of sedation protocols is associated with fewer mechanical ventilation days in critically ill patients. Canadian intensive care units (ICUs) often have a higher nurse-patient ratio and more specialised training of ICU nurses than French ICUs. Considering these differences, the purpose of this study was to compare implementation of sedation protocols as indicated by frequency of sedation assessment and response to levels of sedation between a Canadian and a French ICU.MethodsThis was a retrospective observational study of 30 patients who were mechanically ventilated for at least 24 h in each of two tertiary care ICUs in Vancouver, Canada and Montpellier, France. The authors tabulated all Richmond Agitation-Sedation Scale scores, frequency of score measurement, target scores, frequency and magnitude of scores that were out of target range, and the response to these scores within 1 h of measurement. Practices between the two hospitals were compared using regression modelling, adjusting for patient age, sex, and Acute Physiology and Chronic Health Evaluation (APACHE) II score.ResultsAlthough sedation scores were measured more frequently in the Canadian ICU, there were fewer appropriate adjustments in medications in response to scores that were outside the target range in this ICU than in the French ICU, which had a lower nurse-patient ratio and no specialised training of nurses (OR 0.26 (95% CI 0.13 to 0.50) for scores that were higher than target, and OR 0.14 (95% CI 0.07 to 0.28) for scores that were lower than target).ConclusionDifferences in sedation management between these ICUs are likely related to factors other than nurse-patient ratio or specialised training of ICU nurses.

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