• Ernst-Peter Horn, Berthold Bein, Ole Broch, Timo Iden, Ruwen Böhm, Svea-Kristina Latz, and Jan Höcker.
• From the Department of Anaesthesiology, Regio Klinikum Pinneberg, Pinneberg (E-PH); Department of Anaesthesiology, Asklepios Clinic St. Georg Hamburg, Hamburg (BB); and Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany (OB, TI, RB, S-KL, JH).
• Eur J Anaesthesiol. 2016 May 1; 33 (5): 334-40.

BackgroundEpidural analgesia (EDA) is known to be an independent risk factor for perioperative hypothermia and its many known adverse effects. Combined general and epidural anaesthesia decreases intraoperative core temperature more rapidly than general anaesthesia alone. Hence, adequate warming procedures are needed for these patients.ObjectiveWe evaluated the effects of active skin-surface warming before and/or after initiation of EDA during general anaesthesia as a procedure to prevent perioperative hypothermia.DesignA randomised controlled trial.SettingDepartment of Anaesthesiology in a general hospital in Germany from January 2013 until August 2014.PatientsAfter obtaining written informed consent, we included 99 adult patients undergoing elective major abdominal surgery under combined general anaesthesia and EDA with an expected duration of surgery of at least 120 min. Patients were excluded if they were under 18 years of age, classified as American Society of Anesthesiologists' physical status 4 or higher or if patients refused EDA.InterventionsPatients were randomly assigned to one of three groups and received either only passive insulation, 15 min of active air-forced warming after EDA and before induction of general anaesthesia, or two periods, each of 15 min, of active air-forced warming before and after EDA. Core and skin temperatures were measured at several time points throughout the study.Main Outcome MeasuresThe primary outcome measure was the incidence of hypothermia on arrival in the ICU. The secondary outcome measure was the incidence of postoperative shivering. In addition, the perioperative change in body core temperature was recorded.ResultsWithout prewarming (n = 32), 72% of patients became hypothermic (<36°C) at the end of anaesthesia. Fifteen minutes of warming after insertion of the epidural catheter and before initiation of general anaesthesia reduced the incidence of postoperative hypothermia to 6% (n = 33). After two periods of 15 min of warming before and after insertion of the epidural catheter, no patient became hypothermic (n = 34). Prewarming in either 'warming' group prevents the initial temperature drop which was observed in the control group.ConclusionWarming for 15 min before and after initiation of EDA in patients receiving combined anaesthesia is effective in preventing postoperative hypothermia.Trial RegistrationThis trial was registered with ClinicalTrials.gov (identifier: NCT01795482).

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