• Xinrong He, Fuhong Su, Fabio Silvio Taccone, Leonardo Kfuri Maciel, and Jean-Louis Vincent.
• Department of Intensive Care, Erasme University Hospital, Université Libre de Bruxelles, Belgium.
• Resuscitation. 2012 Jun 1;83(6):760-6.

AimsHypothermia is used for brain protection after resuscitation from cardiac arrest and other forms of brain injury, but its impact on systemic and tissue perfusion has not been well defined. The aim of this study was to evaluate the cardiovascular and microvascular responses to mild therapeutic hypothermia (MTH) in an ovine model.MethodsSeven anaesthetised, mechanically ventilated, invasively monitored sheep were cooled from a baseline temperature of 39-40°C to 34°C using cold intravenous fluids, ice packs and transnasal cooling. After 6h of MTH, sheep were progressively re-warmed to baseline temperature. Positive fluid balance was maintained during the entire study period to avoid hypovolemia. In addition to standard haemodynamic assessment, the sublingual microcirculation was evaluated using sidestream dark-field (SDF) videomicroscopy.ResultsMTH was associated with significant decreases in cardiac index and left (LVSWI) and right (RVSWI) ventricular stroke work indexes. There was a downward shift in the relationship between LVSWI and pulmonary artery occlusion pressure during MTH, indicating myocardial depression. During MTH, mixed venous oxygen saturation increased, in association with reduced oxygen consumption, but blood lactate concentrations increased significantly. There was a significant decrease in the proportion and density of small perfused vessels. All variables returned to baseline levels during the re-warming phase.ConclusionIn this large animal model, MTH was associated with decreased ventricular function, oxygen extraction and microvascular flow compared to normothermia. These changes were associated with increased blood lactate levels. These observations suggest that MTH may impair tissue oxygen delivery through maldistribution of capillary flow.Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

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