• Gad Shaked, George Grinberg, Yuval Sufaro, Amos Douvdevani, Yoram Shapira, Alan Artru, and David Czeiger.
• Department of General Surgery and Trauma Unit, Soroka Medical Centre and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.
• Resuscitation. 2009 Aug 1;80(8):935-9.

BackgroundIn previous studies ketamine was reported to improve survival and decrease serum interleukin-6 (IL-6) concentration after sepsis alone and after burn injury followed by sepsis. The aim of this study was to determine whether ketamine alters survival and/or IL-6 after hemorrhagic shock alone or hemorrhagic shock followed by sepsis.Materials And MethodsRats were subjected to hemorrhagic shock with or without subsequent Gram-negative bacterial sepsis and were either treated with ketamine 5 mg/kg or were not treated. Blood was sampled for IL-6 determination prior to hemorrhage, at the completion of resuscitation, and at 6 and 30 h later. Mortality was recorded for 7 days following hemorrhage or hemorrhage+sepsis.ResultsAfter hemorrhage+sepsis the time to median mortality was significantly later in the ketamine-treated group (36 h) than in the control group (12 h). At 12h the survival rate of the ketamine-treated group (100%) was significantly higher than in the control group (55%). There were no significant differences between groups with respect to IL-6 or 7-day survival after either hemorrhage+sepsis or hemorrhage alone.ConclusionKetamine improved 12h survival and delayed mortality after hemorrhage+sepsis without significantly altering IL-6, and did not alter survival or IL-6 after hemorrhage alone.

26 keywords...

hide…