• A K Shaginian, V A Mikhel'son, and E G Agavelian.
• Anesteziol Reanimatol. 2008 Jan 1(1):29-32.

AbstractThis study has evaluated the efficacy and safety of different doses of Esmerone in children under fluorothane anesthesia. It enrolled 85 children from a senior age group (7-14 years). According to the myorelaxant used, all the patients were divided into 2 groups: S and R. In the S group (n=25), myoplegia was carried out administering succinylcholine in a dose of 1 mg/kg. In the R group, myorelaxation was achieved using rocuronium bromide (Esmerone). According to the dose used, the group was divided into 3 subgroups, each comprising 20 patients. The initial dose of Esmemrone was 0.3, 0.6, and 0.9 mg/kg, respectively. The efficacy of the agent was evaluated by accelerographic and clinical data. The study has demonstrated that Esmerone was safer than succinylcholine. Increasing the dose (0.3-0.6-0.9 mg/kg) of Esmerone advantages in the onset of NMB and shows an increase in the duration of its action.

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