• Resuscitation · Jul 2012

    Randomized Controlled Trial

    BML-111, a lipoxin receptor agonist, protects haemorrhagic shock-induced acute lung injury in rats.

    • Jie Gong, Si Guo, Hong-Bin Li, Shi-Ying Yuan, You Shang, and Shang-Long Yao.
    • Department of Anesthesiology and Critical Care, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
    • Resuscitation. 2012 Jul 1;83(7):907-12.

    ObjectivesThe main pathogenesis of acute lung injury induced by haemorrhagic shock is inflammation. BML-111, a lipoxinA(4)-receptor agonist, promotes acute inflammatory resolution. We sought to elucidate whether BML-111 protects haemorrhagic shock-induced acute lung injury in rats.MethodsThirty two adult male rats were randomized to sham group (sham), haemorrhagic shock/resuscitation (HS), HS plus BML-111 (BML-111), and HS plus BML-111 and BOC-2 (BOC-2). Haemorrhagic shock was induced by blood drawing, and then resuscitation was obtained by infusion of shed blood and two-fold volume saline.ResultsHistological findings, as well as assays of neutrophilic infiltration (myeloperoxidase activity, ICAM-1 expression), inflammatory cytokines and pro-inflammatory factor (IκB-α and NF-κB p65) confirmed that haemorrhagic shock induced acute lung injury. BML-111 significantly mitigated acute lung injury induced by haemorrhagic shock. However, BOC-2, an antagonist of the lipoxinA(4)-receptor, partially reversed the protective effect of BML-111 on the haemorrhagic shock-induced the acute lung injury.ConclusionBML-111 protects haemorrhagic shock-induced acute lung injury in rats.Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

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