• Pediatr Crit Care Me · Jun 2013

    Cardiac dysfunction in pneumovirus-induced lung injury in mice.

    • Reinout A Bem, Elske van den Berg, Ernst Suidgeest, Louise van der Weerd, and Heynric B Grotenhuis.
    • Pediatric Intensive Care Unit, Emma Children's Hospital AMC, Amsterdam, The Netherlands. r.a.bem@amc.uva.nl
    • Pediatr Crit Care Me. 2013 Jun 1;14(5):e243-9.

    ObjectiveTo determine biventricular cardiac function in pneumovirus-induced acute lung injury in spontaneously breathing mice.DesignExperimental animal study.SettingAnimal laboratory.SubjectsC57Bl/6 mice.InterventionMice were inoculated with the rodent pneumovirus, pneumonia virus of mice.Measurements And Main ResultsPneumonia virus of mice-infected mice were studied for right and left ventricular function variables by high-field strength (7 Tesla) cardiac MRI at specific time points during the course of disease compared with baseline. One day before and at peak disease severity, pneumonia virus of mice-infected mice showed significant right and left ventricular systolic and diastolic volume changes, with a progressive decrease in stroke volume and ejection fraction. No evidence for viral myocarditis or viral presence in heart tissue was found.ConclusionsThese findings show adverse pulmonary-cardiac interaction in pneumovirus-induced acute lung injury, unrelated to direct virus-mediated effects on the heart.

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