• Pain · Mar 2000

    Case Reports

    Adverse effects associated with the intrathecal administration of ziconotide.

    • R D Penn and J A Paice.
    • Department of Neurosurgery, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, New York, NY, USA. rpenn@mssm.edu
    • Pain. 2000 Mar 1;85(1-2):291-6.

    AbstractThe omega-conopeptide, ziconotide, is an N-type calcium-channel blocker that has been shown to produce antinociception in animals using formalin and hot-plate tests. Initial reports of intrathecal administration of ziconotide in cancer and AIDS patients whose pain was unrelieved with opioids demonstrated analgesic efficacy. Although adverse effects were reported, these appeared to be easily managed through dose reduction or symptomatic treatment. This clinical report describes the experiences of three patients with serious adverse effects associated with intrathecal ziconotide.

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