• Clinical nuclear medicine · Feb 2011

    Case Reports

    Assessment of cerebral hemodynamics to acetazolamide using brain perfusion SPECT in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.

    • Soon-Ah Park, Chung-Yong Yang, See-Sung Choi, and Woo Hyoung Kim.
    • Department of Nuclear Medicine, Wonkwang University College of Medicine and Institute of Wonkwang Medical Science, Iksan, Republic of Korea.
    • Clin Nucl Med. 2011 Feb 1;36(2):158-9.

    AbstractCerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary microangiopathy caused by mutations in the Notch3 gene located on chromosome 19, leading to 4 cardinal features with aura, cerebrovascular ischemic events, mood disturbances, and dementia. Acetazolamide (ACZ) has been promoted as a drug to determine cerebral hemodynamics, including cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) in patients with cerebrovascular disease. In CADASIL patients with small-vessel disease, ACZ may be possible to increase CBF. We present that reduced CBF was dramatically improved after administration of ACZ on Tc-99m ECD brain perfusion SPECT in a CADASIL patient.

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