• Alicia K Au, Joseph A Carcillo, Robert S B Clark, and Michael J Bell.
• Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. auak@upmc.edu
• Pediatr Crit Care Me. 2011 Sep 1; 12 (5): 566571566-71.

ObjectiveMortality rates from critical illness in children have declined over the past several decades, now averaging between 2% and 5% in most pediatric intensive care units. Although these rates, and mortality rates from specific disorders, are widely understood, the impact of acute neurologic injuries in such children who die and the role of these injuries in the cause of death are not well understood. We hypothesized that neurologic injuries are an important cause of death in children.DesignRetrospective review.SettingPediatric intensive care unit at Children's Hospital of Pittsburgh, an academic tertiary care center.PatientsSeventy-eight children who died within the pediatric intensive care unit from April 2006 to February 2008.InterventionsNone.Measurements And Main ResultsData regarding admission diagnosis, presence of chronic illness, diagnosis of brain injury, and cause of death were collected. Mortality was attributed to brain injury in 65.4% (51 of 78) of deaths. Ninety-six percent (28 of 29) of previously healthy children died with brain injuries compared with 46.9% (23 of 49) of chronically ill children (p < .05). The diagnosed brain injury was the proximate cause of death in 89.3% of previously healthy children and 91.3% with chronic illnesses. Pediatric intensive care unit and hospital length of stay was longer in those with chronic illnesses (38.8 ± 7.0 days vs. 8.9 ± 3.7 days and 49.2 ± 8.3 days vs. 9.0 ± 3.8 days, p < .05 and p < .001, respectively).ConclusionBrain injury was exceedingly common in children who died in our pediatric intensive care unit and was the proximate cause of death in a large majority of cases. Neuroprotective measures for a wide variety of admission diagnoses and initiatives directed to prevention or treatment of brain injury are likely to attain further improvements in mortality in previously healthy children in the modern pediatric intensive care unit.

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