• Shock · Dec 2012

    A combined trauma model of chest and abdominal trauma with hemorrhagic shock--description of a new porcine model.

    • Steffen Ruchholtz, Martijn van Griensven, Philipp Mommsen, Frank Hildebrand, Ingo Witte, Sascha Flohe, Hans-Christoph Pape, Matthias Weuster, Juliane Mohr, Claudia Keibl, and Andreas Seekamp.
    • Trauma Department, Hannover Medical School, Hannover, Germany.
    • Shock. 2012 Dec 1;38(6):664-70.

    AbstractDespite the high incidence and prognostic relevance of hemorrhagic shock and abdominal and blunt chest trauma in multiply injured patients, there are no animal models combining these injuries. Therefore, we established a new porcine multiple trauma model consisting of blunt chest trauma, penetrating abdominal trauma (two incisions in the right upper liver lobe using a four-edged scalpel and subsequent liver packing), and pressure-controlled hemorrhagic shock with a mean arterial pressure of 30 ± 5 mmHg (a maximum of 45% of the total blood volume). The combined traumatic insult led to severe signs of hemorrhagic shock and impaired pulmonary function. In conclusion, a consistent, reproducible, and clinically relevant porcine model of multisystem injury with controlled (pressure-controlled blood withdrawal) and uncontrolled components of hemorrhage (liver laceration) with the potential for rebleeding was established.

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