• Makiko Miyahara, Sumihito Nobusawa, Masato Inoue, Kouichiro Okamoto, Makoto Mochizuki, and Tetsuo Hara.
• Department of Neurosurgery, National Center for Global Health and Medicine, Tokyo, Japan; Advanced and Specialized Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan. Electronic address: mmiyahara@hosp.ncgm.go.jp.
• World Neurosurg. 2016 Feb 1; 86: 515.e1-9.

BackgroundThere are few previous reports of glioblastoma in young adults, in particular, of the very rare recently proposed rhabdoid or epithelioid types.Case DescriptionWe report 2 cases of glioblastoma with rhabdoid features involving a 27-year-old woman and a 41-year-old man. In case 1, the patient presented with generalized seizures, and the initial magnetic resonance imaging showed a very small region of contrast in the left parahippocampal area. After 1 year, the mass suddenly increased in size. Treatment with multiple therapies was administered, but 5 months later, the patient died from multiple systemic metastases. In case 2, the patient presented with a chief complaint of headache for a few weeks. Computed tomography and magnetic resonance imaging showed a left parietal mass with calcification and meningeal dissemination. After undergoing surgical removal, his condition rapidly deteriorated until brain death occurred.ConclusionsGlioblastoma with rhabdoid features may represent a specific pattern of clinical progression that emerges from histologic glioblastoma types.Copyright © 2016 Elsevier Inc. All rights reserved.

14 keywords...

hide…