• Eur. J. Clin. Microbiol. Infect. Dis. · Mar 1991

    Comparative Study Clinical Trial

    Efficacy of clindamycin/primaquine versus trimethoprim/sulfamethoxazole in primary treatment of Pneumocystis carinii pneumonia.

    • B Ruf, I Rohde, and H D Pohle.
    • Department of Internal Medicine, Rudolf Virchow University Hospital (Wedding), Freie Universität Berlin, FRG.
    • Eur. J. Clin. Microbiol. Infect. Dis. 1991 Mar 1;10(3):207-10.

    AbstractMild to moderately severe Pneumocystis carinii pneumonia in patients with AIDS was treated in a clinical trial with a combination regimen of primaquine and clindamycin, and the efficacy of this regimen was compared with that of the conventional treatment regimen of trimethoprim/sulfamethoxazole. The results revealed that primaquine/clindamycin appears to be an equally effective alternative to trimethoprim/sulfamethoxazole. The spectrum of side-effects was similar for the two regimens; side-effects occurred with equal frequency but appeared to be less severe in patients given primaquine/clindamycin. Because therapy with primaquine and clindamycin was limited to patients with mild to moderate Pneumocystis carinii pneumonia, studies with this regimen in more severe cases are warranted.

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