• Feras I Hawari, Lama H Nazer, Awad Addassi, Dalia Rimawi, and Khaled Jamal.
• 1Department of Medicine, Section of Pulmonary and Critical Care, King Hussein Cancer Center, Amman, Jordan.2Cancer Control Office, King Hussein Cancer Center, Amman, Jordan.3Department of Pharmacy, King Hussein Cancer Center, Amman, Jordan.4Department of Scientific Affairs and Research, King Hussein Cancer Center, Amman, Jordan.
• Crit. Care Med. 2016 Mar 1; 44 (3): 548-53.

ObjectiveTo identify factors predictive of admission of patients with cancer to an ICU. In addition, the study aimed to describe the characteristics and outcomes, both short-term and long-term, of patients with cancer admitted to the ICU.DesignRetrospective case-control study, utilizing the institution's cancer registry.SettingComprehensive cancer center.PatientsPatients with cancer. The case group consisted of patients who required ICU admission during the study period, whereas the control group consisted of patients who did not require ICU admission.InterventionNone.Measurements And Main ResultsThe patient characteristics and outcomes were recorded. Univariate and multivariate analyses were conducted to determine factors associated with ICU admission. The registry included 10,792 patients, and among those, 2,439 patients (22.6%) required ICU admission after a median of 10.1 months (interquartile range, 3.28-25.2). The following factors were associated with ICU admission: hematologic malignancy (odds ratio, 1.51; 95% CI, 1.26-1.81), chemotherapy (odds ratio, 1.74; 95% CI, 1.48-2.03), advanced cancer (odds ratio, 2.57; 95% CI, 1.44-4.60), and smoking (odds ratio, 1.38; 95% CI, 1.20-1.61). The most common ICU admission diagnoses were sepsis (21.5%) and respiratory insufficiency/failure (25.7%). The ICU mortality was 36.5%, whereas the 1-year and 5-year survival rates were 22.8% and 14.2%, respectively.ConclusionIn a comprehensive cancer center, about one fourth of the patients required ICU admission. Addressing modifiable risk factors associated with ICU admission is essential to potentially reduce ICU admissions and improve long-term survival.

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