• A Abad-Gurumeta, J Ripollés-Melchor, R Casans-Francés, A Espinosa, E Martínez-Hurtado, C Fernández-Pérez, J M Ramírez, F López-Timoneda, J M Calvo-Vecino, and Evidence Anaesthesia Review Group.
• Department of Anaesthesia, Hospital Universitario la Paz, Madrid, Spain.
• Anaesthesia. 2015 Dec 1; 70 (12): 1441-52.

AbstractWe reviewed systematically sugammadex vs neostigmine for reversing neuromuscular blockade. We included 17 randomised controlled trials with 1553 participants. Sugammadex reduced all signs of residual postoperative paralysis, relative risk (95% CI) 0.46 (0.29-0.71), p = 0.0004 and minor respiratory events, relative risk (95% CI) 0.51 (0.32-0.80), p = 0.0034. There was no difference in critical respiratory events, relative risk (95% CI) 0.13 (0.02-1.06), p = 0.06. Sugammadex reduced drug-related side-effects, relative risk (95% CI) 0.72 (0.54-0.95), p = 0.02. There was no difference in the rate of postoperative nausea or the rate of postoperative vomiting, relative risk (95% CI) 0.94 (0.79-1.13), p = 0.53, and 0.87 (0.65-1.17), p = 0.36 respectively.© 2015 The Association of Anaesthetists of Great Britain and Ireland.

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